Function of Polygonum cuspidatum

(a) related to immunization

Anthraquinones extracted from Polygonum cuspidatum have cytotoxic effect and obviously inhibit the growth of HL-60 cells, among which emodin is the strongest.

For cyclophosphamide-induced leukopenia, Polygonum cuspidatum decoction can significantly increase rats' leukopenia by intragastric administration. Its whitening effect is better than vitamin B4 and Spatholobus suberectus.

Polygonum cuspidatum can inhibit the release of H202 from neutrophils in burned mice, reduce the secretion of lysosome, and adjust or improve the excessive activation of complement.

(2) Anticoagulant and lipid-lowering

Inhibition of platelet aggregation, resveratrol can obviously inhibit induced platelet aggregation in rabbits. Resveratrol can block the action of platelet α2- receptor, inhibit calcium influx, promote the release of PGl2, and reduce the production of TXA2, which may be an important mechanism for resveratrol to inhibit platelet aggregation and prevent thrombosis. Tannin from Polygonum cuspidatum can significantly resist H2 O2 induction

Hemolysis.

To protect vascular endothelial cells, intravenous injection of resveratrol glycoside can reduce venous thrombosis and endothelial cell injury after blood stasis in rat island flap, and its mechanism may be to alleviate histological damage caused by lipid peroxidation and fibrinogen.

Resveratrol and resveratrol glycoside can reduce serum and liver lipids. Reduce serum cholesterol, triglyceride and low density lipoprotein; Elevate high density lipoprotein.

(3) Cardiovascular

Heart strengthening: Resveratrol glycoside has obvious positive inotropic effect on working heart, but does not accelerate heart rate. It can increase the contraction amplitude of isolated guinea pig heart, enhance myocardial contractility, improve circulation and increase coronary flow.

Intraperitoneal injection of Polygonum cuspidatum injection in mice can obviously increase myocardial nutritional blood flow, and has synergistic effect with aminophylline.

Vasodilation of microvessels: After injection of resveratrol glycoside in rats with severe hemorrhagic shock, the diameter of contracted tertiary artery and vein returned to the original level, blood pressure rose moderately, and pulse pressure returned to normal. Arterial blood flow appears at the capillary opening, which promotes the stagnant blood flow to resume, thus improving the disturbance of shock microcirculation.

Anti-arrhythmia: For experimental ventricular tachycardia in rats, Polygonum cuspidatum decoction and resveratrol glycoside can quickly restore sinus heart rate.

(4) Protecting the liver

Enzyme-lowering: Resveratrol and resveratrol glycoside can obviously inhibit the damage and destruction of liver cells caused by lipid peroxidation in rat liver microsomes, and can reduce serum GPT, GOT and liver LP0. Polygonum cuspidatum decoction can restore normal liver function and clear jaundice by promoting the repair and regeneration of animal hepatocytes and relieving inflammation.

Inhibition of HBsAg: Polygonum cuspidatum decoction can inhibit HBsAg, and emodin and flavonoids can reduce the titer of hepatitis B antigen by 8 times. Phenol glycoside also has a weak inhibitory effect on HBsg.

Polygonum cuspidatum has obvious effects of increasing bile secretion in liver and relaxing Oddi sphincter, so it is beneficial to biliary function.

(5) Antibacterial, antiviral and anticancer

Antibacterial activity: Anthraquinones and stilbenes from Polygonum cuspidatum have broad-spectrum antibacterial activity. Resveratrol has strong antibacterial activity against many pathogenic fungi.

Antivirus: Polygonum cuspidatum decoction has strong inhibitory effect on Asian influenza virus, echovirus, Coxsackie virus, herpes simplex virus, adenovirus and other viruses.

Anti-cancer: Polygonum cuspidatum emodin has obvious curative effect on Sl80 of mice, liver cancer of mice, breast cancer of mice, Ehrlich ascites cancer of mice and lymphosarcoma of mice. Tannin from Polygonum cuspidatum has the functions of resisting and promoting cancer and preventing canceration.

(6) Others

Significantly inhibit the swelling of rat feet caused by egg white. Inhibition of auricle swelling induced by croton oil.

Resveratrol glycoside can obviously prolong the sleep time of mice, and has synergistic effect with pentobarbital sodium.

Has analgesic effect on trauma.

External application of this decoction has hemostatic effect. Oral administration has hemostatic effect on upper gastrointestinal bleeding.

Polygonum cuspidatum flavonol glycoside has diuretic effect.

External application of this decoction has anti-infection and anti-inflammatory effects on burn wounds.

It can reduce the incidence and mortality of animal diabetes.

Polygonum cuspidatum decoction, resveratrol glycoside and emodin have antitussive effects. Polygonum cuspidatum decoction can resist histamine-induced tracheal contraction in guinea pigs in vitro, but has weak antispasmodic and antiasthmatic effects.

Tannin from Polygonum cuspidatum has obvious hydroxyl radical scavenging effect.