The pharmacological effects of paeoniflorin from peony extract

Pharmacological effects:

    1. Effects on the central nervous system

    Paeoniflorin has obvious analgesic, sedative and anticonvulsant effects. Peony extract can antagonize the convulsions caused by strychnine. The analgesic effect may not be related to morphine receptors. It can prolong the sleep time of mice and antagonize the convulsions caused by pentylenetetrazol.

    2. Impact on the cardiovascular system

    Vasodilation: Paeoniflorin can dilate coronary arteries, increase coronary flow, resist acute myocardial ischemia, and lower blood pressure.

The pharmacological effects of paeoniflorin from peony extract

    Cerebral ischemia protection: the effect of paeoniflorin on the blood-brain barrier and cerebral ischemic neuropathy symptoms, cerebral ischemia-reperfusion cerebral blood flow. The results show that paeoniflorin has a protective effect on brain edema, blood-brain barrier and local cerebral blood flow after cerebral ischemia. Paeoniflorin can significantly reduce the degree of cerebral edema, reduce the scope of cerebral infarction, improve neurobehavioral symptoms, blood-brain barrier permeability, and increase local blood flow in the brain. The protective mechanism may be related to the following factors: inhibit intracellular calcium overload, resist free radicals, improve ischemia and hypoxia caused by cerebral vasomotor dysfunction, protect the blood-brain barrier after cerebral ischemia and reperfusion, and promote economy Reperfusion cerebral blood flow early in resuscitation.

    3. The effect of antispasm

    It can inhibit the movement of intestine, stomach and uterine smooth muscle in rats and guinea pigs, and antagonize the uterine contraction caused by oxytocin. At the same time, some scholars have used Baishaofang to treat irritable bowel syndrome and recurrent colonic cholelithiasis after surgery, and achieved certain effects. By relaxing the sphincter, paeoniflorin facilitates the excretion of bile and pancreatic juice during acute pancreatitis, thereby reducing the activation of pancreatic enzymes, reducing pancreatic acinar damage, and ultimately reducing the severity of acute pancreatitis.

    4. Antipyretic, anti-inflammatory, anti-ulcer and anti-allergic effects

    Paeoniflorin has a cooling effect on normal mice and a heat transfer effect on artificial fever mice. Paeoniflorin can inhibit carrageenan and dextran-induced ankle joint swelling in rats, prevent adjuvant arthritis in rats, prevent stress ulcers in rats, and inhibit gastric juice secretion. Baishao Tang has an inhibitory effect on some pathogens and fungi.

    5. The impact of hypoglycemia

    Paeoniflorin can significantly reduce the blood sugar of diabetic mice induced by streptozotocin, and with the extension of the medication time, the plasma sugar content gradually decreases. The effect is strongest 25 minutes after administration. Paeoniflorin can reduce plasma sugar levels, and its effect is related to the content of paeoniflorin. The results show that the blood sugar-lowering mechanism of paeoniflorin has nothing to do with insulin.